Clinical Studies
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Evaluating Benefit of a Novel Intra-articular Device in Dogs With a Suspected Cruciate Ligament Tear
Currently EnrollingThis pilot study in dogs with suspected cranial cruciate ligament rupture seeks to determine whether a benefit is seen through the intra-articular injection of a novel veterinary device product in the affected stifle joint.
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Evaluating the Tolerability of a Novel PCNA Inhibitor in Dogs with Cancer
Currently EnrollingProliferating cell nuclear antigen (PCNA) is an important protein necessary for the repair of DNA in cells. Cancer cells express a unique type of PCNA (termed caPCNA) which is only found at small quantities in non-cancer cells.
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Omics Research-Based Identification of Targets in Sepsis (ORBITS)
Currently EnrollingSepsis is caused by a severe infection that enters the bloodstream and is associated with a high mortality rate. This high mortality rate has remained unchanged over the last three decades even though there has been active research in the area.
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Tolerability of Oral Paclitaxel in Cancer-Bearing Dogs
ClosedResearch Type Ethos Discovery De Novo Study Description Paclitaxel is a human chemotherapeutic that has demonstrated a broad spectrum of activity against several human and canine cancers. Previous formulations of paclitaxel have been poorly absorbed in dogs, limiting its therapeutic value. Oraxol is a novel oral formulation of paclitaxel that is combined with a second
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Canine Mast Cell Tumor Study
ClosedThis study will evaluate whether or not a small biopsy from a mast cell tumor is accurate for prognostication purposes.
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Ethos Precision Medicine Umbrella Study for Hemangiosarcoma (Ethos-PUSH)
Currently EnrollingEthos Discovery now seeks to deliver a highly advanced clinical trial program investigating the use of novel drugs for the treatment of Hemangiosarcoma (HSA) with the goal of curing this aggressive cancer. This study will ask if drugs specifically matched to the genomic subtypes of patients with HSA will result in improved outcomes.
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Dysbiosis Enhancing Linkage Towards Association with Canine Osteosarcoma (DEL-TACO Lite)
Currently EnrollingIntestinal dysbiosis has been associated with tumor progression of colorectal, lung, and breast cancer in human patients. The objective of this study is to determine whether or not canine patients diagnosed with osteosarcoma have intestinal dysbiosis and if the presence of intestinal dysbiosis is associated with metastasis in these patients.
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Sorafenib for the Treatment of Solid Tumors in Dogs
ClosedWe have previously reported on the tolerability and hints of clinical activity of Sorafenib in dogs with cancer. This background provides a rationale for the further study of Sorafenib in dogs with cancer. In this study we seek to define an optimal dosing schedule for Sorafenib and will assess its tolerability and activity in dogs with solid tumors.
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Rapamycin for the Treatment of Hemangiosarcoma in Dogs
ClosedBased on its reported tolerability in dogs (alone and in combination with chemotherapy) this study will ask whether Rapamycin may improve treatment outcomes for dogs with hemangiosarcoma, and more precisely, to understand the hemangiosarcoma genotypes which may most benefit from its use.
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