Clinical Studies
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Intra-articular Injection for the Treatment of Canine Elbow Dysplasia
OpenA new veterinary device composed of collagen and elastin particles has been developed; it has been shown to help protect cartilage from mechanical grinding. Previous anecdotal use of this product has been beneficial in dogs with elbow dysplasia.
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Evaluating Benefit of a Novel Intra-articular Device in Dogs With a Suspected Cruciate Ligament Tear
ClosedA new veterinary device composed of collagen and elastin particles has been developed; it is delivered via intra-articular injection and helps protect cartilage from mechanical grinding. This study seeks to validate this device as a pre-surgical management tool for dogs with cruciate disease.
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Evaluating the Tolerability of a Novel PCNA Inhibitor in Dogs with Cancer
ClosedProliferating cell nuclear antigen (PCNA) is an important protein necessary for the repair of DNA in cells. Cancer cells express a unique type of PCNA (termed caPCNA) which is only found at small quantities in non-cancer cells.
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Tolerability of Oral Paclitaxel in Cancer-Bearing Dogs
ClosedResearch Type Ethos Discovery De Novo Study Description Paclitaxel is a human chemotherapeutic that has demonstrated a broad spectrum of activity against several human and canine cancers. Previous formulations of paclitaxel have been poorly absorbed in dogs, limiting its therapeutic value. Oraxol is a novel oral formulation of paclitaxel that is combined with a second
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Canine Mast Cell Tumor Study
ClosedThis study will evaluate whether or not a small biopsy from a mast cell tumor is accurate for prognostication purposes.
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Ethos Precision Medicine Umbrella Study for Hemangiosarcoma (Ethos-PUSH)
OpenIs your dog undergoing surgery for a ruptured splenic tumor? Ethos Discovery would love to have you and your dog participate in our clinical trial! We are evaluating drugs for the treatment of HSA with the goal of curing this aggressive cancer.
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Dysbiosis Enhancing Linkage Towards Association with Canine Osteosarcoma (DEL-TACO Lite)
OpenThis study aims to determine whether or not canine patients diagnosed with canine osteosarcoma (OSA) have intestinal dysbiosis and whether treating intestinal disease improves patient outcomes.
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Sorafenib for the Treatment of Solid Tumors in Dogs
ClosedWe have previously reported on the tolerability and hints of clinical activity of Sorafenib in dogs with cancer. This background provides a rationale for the further study of Sorafenib in dogs with cancer. In this study we seek to define an optimal dosing schedule for Sorafenib and will assess its tolerability and activity in dogs with solid tumors.
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Rapamycin for the Treatment of Cancer in Dogs
OpenThis study seeks to understand the intestinal absorption potential of a novel formulation of rapamycin when administered to dogs with naturally occurring cancer. The data from this study will be used to define an ideal dose of the drug to use in future cancer clinical studies.
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